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星期四, 九月 30, 2010
国际学术同仁声援肖传国医生的公开信
国际学术同仁声援肖传国医生的公开信
2010年9月29日
致所有人：
我们都有幸认识肖传国大夫多年。他是一位受国际学术界尊敬的外科医生和科学家，在恢复（脊椎损伤病人的）排尿和排便功能的神经再生研究中，他取得了重大进展。肖传国医生在美国完成了开创性的动物实验研究，阐明支配大腿的运动神经可以用来绕接支配膀胱和排便。这个绕接可以形成一个反射作用（反射弧）来启动来膀胱功能。他研究的成果已经多次发表在同行评议的国际科学期刊上。其他的科学家也已经重复并证实了肖医生的这些研究结果。
肖医生最终鼓起勇气将动物实验研究的成果转化到临床试验上，在中国的脊柱损伤和脊柱裂病人身上开展神经绕接（神经通路重建，即反射弧）手术。在中国，由于缺乏抗痉挛药物antimuscarinics和间歇性导尿术（自插导尿管），神经性膀胱功能障碍成为一种威胁生命的疾病。能缓解神经性膀胱功能障碍的并发症的疗法，就是一种能够拯救生命的成功。神经性膀胱和排大便功能障碍患者的病情是很痛苦的，包括遭受尿潴留、尿失禁、反复感染、肾功能不全、大便失禁、便秘等，生活质量极差。神经通路重建手术是一个非常复杂的手术，需要神经的再生。不应当把手术的成功定义为完全恢复排便排尿功能。这项手术的重点在于收益超过风险。
肖医生的临床研究成果发表在多种学术刊物上，并两次获得Jack Lapides佳作奖，这是奖励在神经泌尿科学界作出重要贡献的科学家的最崇高的国际性大奖之一。2008年，因为他的科学成就，肖医生还获得了国际儿童排尿节制学会颁发的Kelm Hjalmas演讲者（受邀做大会主题发言）荣誉。我们当中的许多人都曾经到中国去检视肖医生治疗过的患者的情况，观摩或者学习他发明的神经通路重建手术。肖医生是一位非常有经验的外科医生，他对患者热情照顾，不知疲倦地培训来自世界各地的医生们，来推广他的神经通路重建手术。
在美国，已经开展过一项独立而且严格的先期试验来检验这项手术的安全性和效益。术后一年的治疗结果最近发表在《泌尿科学杂志》（ Journal of Urology）上。在12个月的随访期间，在9位脊髓裂患者中，有7位患者，观察到皮下至膀胱的神经反射弧的构建成立，证明神经通路重建手术的确起了作用。这个成绩是了不起的，肖医生应该得到嘉奖。并且，一部分患者已经展现出大小便排便功能的改善，并将随时间推移而变得更好。术后36个月的成果正在分析中，不久就会发表。该先期试验的数据是支持“肖氏手术”的，现在受NIH（美国国立卫生研究院）资助的临床试验正在开展，以进一步在脊髓裂患者中研究腰椎至骶神经通路重建。还有，在肖医生的帮助和指导下，类似的临床试验也在世界范围内开展。
中国人民和政府应该为肖医生对病人所作出的贡献、对他的科学成就，和他在世界上培训医生以推广这项手术的诚意而自豪。国际科学界对肖医生被拘捕的消息感到震惊。我们这些了解肖医生的人，都对他涉入此案感到难以置信。
肖医生是一个极富同情心的绅士，他的诚实和对本学科作出的开创性的科学成就广受世界同行的尊敬。我们恳请中国政府和有关权威机构公正对待肖大夫，并在案情调查期间保障他的基本人权。在此事件中，请重视肖大夫对世界所作出的科学和人道主义事业的贡献。
谨致
Kenneth M. Peters, MD
Professor and Chairman of Urology
Beaumont Hospital
Royal Oak, Michigan
（美国Beaumont医院泌尿科主任、教授，医学博士）
Jack S. Elder, M.D.
Chief of Urology, Henry Ford Health System
Associate Director, Vattikuti Urology Institute
Department of Urology, Children's Hospital of Michigan
Clinical Professor of Urology, Case School of Medicine
(美国密西根儿童医院泌尿科主任，医学博士，医学教授)
Edwin A. Smith M.D.
Assistant Clinical Professor of Urology
Emory University School of Medicine
Atlanta, Georgia
（美国艾默里大学医学院临床助理教授，医学博士）
Kevin M. Feber, MD, FAAP
Board Certified in Pediatric Urology
Comprehensive Urology
William Beaumont Children's Hospital
（美国William Beaumont儿童医院医生，医学博士）
Ananias C. Diokno, M.D., F.A.C.S.Executive Vice President & CMOBeaumont HospitalRoyal Oak, Michigan 48073 USA
（美国Beaumont医院执行副总裁，医学博士）
Juan José de Benito
Urologist
Hospital Nacional de Clínicas
Córdoba, Argentina.
（阿根廷国立医院泌尿科医生）
William E. Nantau B.Sc., CNIMClinical ManagerClinical Neurophysiology DepartmentBeaumont Hospital Royal Oak
（美国Beaumont医院临床神经生理科临床主管）
Evan J Kass MD,FACS,FAAPChief, Division of Pediatric UrologyBeaumont Childrens HospitalProfessor of Urology, Oakland University-William Beaumont School of Medicine
（美国Beaumont儿童医院泌尿科主任，奥克兰大学医学院教授）
Jacques Corcos MD.Professor of Urology, McGill UniversityGeneral Secretary of the International Continence SocietyJewish General hospital3755 Cote Ste-CatherineMontreal, Quebec, Canada H3T 1E2
（加拿大麦基尔大学泌尿学教授，医学博士，国际儿童排尿节制学会秘书长）
Jose Gonzalez, M.D.
Department of Urology
Beaumont Hospital
Royal Oak, Michigan
（美国Beaumont医院泌尿科医生，医学博士）
Christopher Payne, MD
Associate Professor of Urology
Stanford University Medical School
Stanford, CA 94305-5118
（美国斯坦福大学医学院泌尿学副教授，医学博士）
Kenneth I. Glassberg, MD
Director, Division of Pediatric Urology
Morgan Stanley Children's Hospital of New York-Presbyterian
Professor of Urology, Columbia University
College of Physicians and Surgeons
3959 Broadway, CHN 1118
（美国哥伦比亚大学医学院泌尿学教授，儿童泌尿学分科主任，医学博士）
Earl Y. Cheng, MD
Associate Professor of Urology
Children’s Memorial Hospital
Chicago, Illinois
（美国芝加哥儿童医院泌尿学副教授，医学博士）
Darius J. Bagli, MDCM
Professor of Surgery
Senior Associate Scientist
Director of Urology Research
Divisions of Urology and
Developmental & Stem Cell Biology
The Hospital For Sick Children
Institute of Medical Science
University of Toronto
（加拿大多伦多大学外科学教授，泌尿学研究主任）
Henri B. LOTTMANN, MD, FEBU, FEBPS, FRCS(england) FEBPU
Paediatric urology unit
Hopital Necker-Enfants-Malades
149, rue de Sèvres
75015 Paris
France
（法国Necker-Enfants-Malades医院儿童泌尿科医生，医学博士）
Dr. Amrish Vaidya MS. MCh.Consultant Paediatric Surgeon,Kokilaben Dhirubhai Ambani Hospital,4 Bungalows, Andheri W, Mumbai, India
（印度Kokilaben Dhirubhai Ambani医院医生）
Marc Cendron, MD
Associate Professor in Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA
（美国哈佛大学医学院泌尿学副教授，医学博士）
Stuart B. Bauer, MD
Associate Director, Neurourology
Professor of Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA
（美国哈佛大学医学院泌尿学教授，波士顿儿童医院神经泌尿科副主任，医学博士）
Edmond T. Gonzales, Jr., MD
Professor of Urology
Baylor College of Medicine
（美国贝勒医学院泌尿学教授，医学博士）
Richard Macchia, MD FACS
SUNY Distinguished Teaching Professor
Cleveland Clinic, Florida
（美国Cleveland临床中心教授，医学博士）
Benjamin Girdler, MD
Urology Center of the Rockies
Fort Collins, Colorado
（美国科罗拉多洛基泌尿中心医生，医学博士）
William C. de Groat, Ph.D.
Professor of Pharmacology
University of Pittsburgh
（美国匹兹堡大学药理学教授，博士）
Michael R. Ruggieri, Sr., Ph.D.
Director of Urologic Research
Temple University School of Medicine
（美国坦普大学医学院泌尿学研究主任，博士）
Stanley J Kogan MD
Chief, Pediatric UrologyChildren's Hospital at MontefioreBronx NY USA
（美国Montefiore儿童医院儿童泌尿科主任，医学博士）
Anthony Caldamone, MD
University Urologic Associates, Inc.2 Dudley St Ste 185Providence, RI 02905
（美国布朗大学泌尿学中心医生，医学博士）
Yves Homsy MD, FRCSC, FAAP Clinical Professor of Urological Surgery and Pediatrics University of South Florida Children's Urology Group 5507 E. Longboat Blvd Tampa FL 33615
（美国南弗罗里达大学临床泌尿学教授，医学博士）
Dr. Enrique Turina
Professor of urology of the National University of Buenos Aires
Chief of section Urology of Instituto de Rehabilitación
Government of Buenos Aires, Argentina.
（阿根廷国立Buenos Aires大学泌尿学教授，博士）
Dr. Angel Ozón
Urologist of the Instituto de Rehabilitación of Buenos Aires
（阿根廷国立Buenos Aires大学泌尿学医生，博士）
Dr. Daniel Ekizian
Urologist of Instituto de Rehabilitación.
（阿根廷国立Buenos Aires大学泌尿学医生，博士）
Professor Dr. med. Karl-Dietrich Sievert
Vice Chair Prof. of Urology, Director - Uro-oncology, Neurourology, Incontinence, & Reconstructive Urology Department of Urology University of Tuebingen D72076 Tuebingen, Germany
（德国Tuebingen大学泌尿学主任、教授，博士）
Holly Gilmer, MD
Chief of Pediatric Neurosurgery
Beaumont Hospital
Royal Oak, Michigan
（美国Beaumont医院儿童神经外科主任，医学博士）
Yegappan Lakshmanan, MD
Chief, Pediatric Urology
Children’s Hospital of Michigan
（美国密西根儿童医院儿童泌尿科主任，医学博士）
英文原文：
Open letter in support of Chuan-Guo Xiao, M.D. from the International Academic Community
September 29, 2010
To all:
We have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years. He is an internationally respected surgeon-scientist who has made major advances in the development of neuroregeneration to restore voiding and bowel function. Dr. Xiao performed groundbreaking animal research in the United States, demonstrating that a motor nerve that innervates the leg can be used to reinnervate the bladder and bowel. This reinnervation allows for development of a reflex to initiate bladder function. The results of his studies were published in peer-reviewed journals and other scientists have replicated Xiao’s findings confirming these results.
Dr. Xiao eventually took the courageous step of moving from animal research to human studies and began performing the rerouting procedure on patients with spinal cord injury and spina bifida in China.
Neurogenic bladder is life threatening in China due to a lack of both antimuscarinics and intermittent catheterization, and lessening the complications of neurogenic bladder would be considered a lifesaving success. Patients with neurogenic bladder and bowel suffer greatly and endure a host of issues such as urinary retention, incontinence, recurrent infections, renal insufficiency, fecal incontinence, constipation, and poor quality of life. For a procedure as complicated as nerve rerouting requiring nerve regeneration, one cannot expect normalization of bladder and bowel function to be the definition of success. What is important is that the benefits outweigh the risks of the procedure.
Dr. Xiao published his clinical results in peer-reviewed journals and was twice honored by the Jack Lapides Essay Contest, one of the most respected international awards given to scientists who make major contributions to the field of neurourology. In 2008, he was named the Kelm Hjalmas Memorial Lecturer from the International Children’s Continence Society for his scientific achievements. Many of us have traveled to China to examine patients treated by Dr. Xiao and/or have been trained by him in the nerve rerouting surgery he invented. Dr. Xiao is a very skilled surgeon who is passionate about patient care and works tirelessly to train physicians around the world in performing his nerve rerouting procedure.
In the United States, an independent and very rigorous pilot research trial was performed to test the safety and efficacy of this procedure. The one-year results were recently published in the Journal of Urology. At the 12-month follow-up visit, a cutaneous to bladder reflex was found in 7 of 9 spina bifida patients, confirming that rerouting does occur. This finding by itself is remarkable and Dr. Xiao should be commended. In addition, a number of patients demonstrated improvement in bladder and bowel function, which has continued to improve with longer patient follow-up. The 36-month results are currently being analyzed and will be reported in the near future. The pilot data was supportive of Dr. Xiao’s procedure, and now an NIH sponsored clinical trial is being conducted to further study lumbar to sacral nerve rerouting in spina bifida patients. In addition, similar procedures have been done worldwide, with Dr. Xiao helping to mentor the surgeons at each site.
The Chinese people and government should be proud of Dr. Xiao for his dedication to his patients, his scientific achievements, and his willingness to train doctors around the world how to perform his surgery. The International scientific community was shocked to hear of Dr. Xiao’s arrest. Those of us who know Dr. Xiao well find it difficult to believe that he is involved in these attacks.
Dr. Xiao is a compassionate man who is respected worldwide for his integrity and his innovative scientific contributions to society. We implore the Chinese government and authorities to treat Dr. Xiao fairly and to protect his human rights as these charges are investigated. Please strongly consider Dr. Xiao’s scientific and humanitarian contributions to the world as facts are gathered in this case.
Sincerely,
（签名略）
发出该信的Wise Young（杨咏威）教授的附言
我一直很不愿意评论这件事情，因为缺乏足够证据。你们（新语丝自愿者）关于肖医生成功率的所谓“调查”，是由没有评估病情资格的、长期批评肖医生的方先生的律师作出的。通常来说，在科学和医学领域，结果是由另一类调查、由进行类似研究的人员做出，看是否能够复制这个结果。
就他的信用而言，肖医生在过去五年，一直非常努力致力于传授他的手术给其他医生，并且鼓励他们去从事并公布解除膀胱麻痹的肖氏手术的临床实验结果。Peters医生在密歇根奥克兰大学William Beaumont医院进行的第一个临床实验报告，在the Journal of Urology（《泌尿学杂志》）期刊上公布了。据我所知，斯堪的纳维亚半岛（北欧国家）的其他实验结果也会很快公布。肖医生公布了他的研究结果。他的研究报告并不难找到。
我鼓励人们研究那些报告，通过自己独立思考而得出结论。我不想把我对这些报告的认识强加于人，直到人们有机会阅读了那些报告，讨论那些结果。现在，我附上国际学术界关于肖医生和关于他被拘禁新闻的一封信。这封信对肖医生表示了强烈支持，并且已经由一些相关领域的最著名的泌尿学家和科学家签了名。
英文原文：
I have been reluctant to comment on this matter in large part because there is insufficient evidence. The so-called "investigation" of Dr. Xiao's results that you describe was carried out by a lawyer who is not qualified to assess patients and apparently affiliated with Mr. Fang, a long-time critic of Dr. Xiao. Normally, in science and medicine, results are confirmed by other investigators who do similar studies to ascertain whether the results can be replicated.
To his credit, Dr. Xiao has been working very hard over the past 5 years to teach his procedure to other doctors and to encourage them to do and publish clinical trials of the Xiao method of treating bladder paralysis. The results of the first clinical trial by Dr. Peters at the Oakland University William Beaumont Hospital in Michigan, was recently published in the Journal of Urology. I understand that other studies in Scandinavia will be published soon. Dr. Xiao has published his work. It is not difficult to find the studies.
I urge people to come to their own conclusions concerning the results. I do not want to impose my opinions concerning the results until people have had a chance to read the work and discuss the results. In the meantime, I attach a letter from the international academic community concerning Dr. Xiao and the news concerning his incarceration. This letter is very supportive of Dr. Xiao and has been signed by some of the most prominent urologists and scientists in the field.
按：Wise Young（杨咏威）教授是美国美国Rutgers大学讲席教授、细胞生物学和神经科学系主任、Keck国际合作神经科学中心主任、中国脊髓损伤研究协作组(China SCI Net)董事会联席主席。Rutgers大学的脊髓损伤论坛，由他负责主持。
香港中文大学的简介：
杨咏威教授 (Dr. Wise Young) 是全球脊椎治疗权威之华裔学人，现担任新泽西州 罗格斯大学 (Rutgers University) 神经科学系 (Cell Biology & Neuroscience) 教授兼系主任，以致力协助脊椎伤患恢复身心能力而在医学界有「神经建造者」或「神经建筑师」之誉。他于 2001 年获《时代》杂志选为美国十八位最佳科学家及医生之一，入选者当中有两名华人，另一名是治疗爱滋病的专家何大一。
Wise Young（杨咏威）教授官方网页
23:16 发表在 方舟子“打假” | 查看全文 | 评论 (2)
评论
张三同志，猫来找您串联咯O(∩_∩)O，邮箱留给您，到时可得联系哦。
发表人： 咕咕猫 | 星期六, 十月 02, 2010
辗转至此，终于找到三哥的blog,不错。存档以后慢慢看。
发表人： 晴斋 | 星期二, 十月 19, 2010